Gene information
Official symbol THBS1
Official full name thrombospondin 1
Gene type protein-coding gene
Chromosome15q14
Alias symbolTSP1; THBS; TSP; THBS-1; TSP-1
Resources
Entrez Gene 7057
HGNC HGNC:11785
Ensembl ENSG00000137801
Vega OTTHUMG00000133665
UCSC uc001zkh.4
GO terms: 227 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001786 phosphatidylserine binding GO Molecular Functions -3.87607272 6 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001952 regulation of cell-matrix adhesion GO Biological Processes -7.29794194 21 More
GO:0001953 negative regulation of cell-matrix adhesion GO Biological Processes -4.47602531 9 More
GO:0001968 fibronectin binding GO Molecular Functions -9.79576986 9 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002544 chronic inflammatory response GO Biological Processes -7.69370672 5 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005198 structural molecule activity GO Molecular Functions -7.51921139 30 More
GO:0005201 extracellular matrix structural constituent GO Molecular Functions -12.8379048 20 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006897 endocytosis GO Biological Processes -8.07395492 24 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006911 phagocytosis, engulfment GO Biological Processes -3.88108165 8 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006986 response to unfolded protein GO Biological Processes -2.24519355 6 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009408 response to heat GO Biological Processes -9.27499209 13 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010324 membrane invagination GO Biological Processes -3.48951254 8 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010749 regulation of nitric oxide mediated signal transduction GO Biological Processes -3.60391289 3 More
GO:0010755 regulation of plasminogen activation GO Biological Processes -10.5063145 8 More
GO:0010758 regulation of macrophage chemotaxis GO Biological Processes -10.4093121 9 More
GO:0010759 positive regulation of macrophage chemotaxis GO Biological Processes -7.10577702 6 More
GO:0010763 positive regulation of fibroblast migration GO Biological Processes -3.56180292 5 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010812 negative regulation of cell-substrate adhesion GO Biological Processes -8.89322529 17 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0010955 negative regulation of protein processing GO Biological Processes -5.65848894 6 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO Biological Processes -7.26381098 23 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030169 low-density lipoprotein particle binding GO Molecular Functions -10.8464740 8 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032026 response to magnesium ion GO Biological Processes -3.03478521 5 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0032570 response to progesterone GO Biological Processes -4.02622258 5 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032695 negative regulation of interleukin-12 production GO Biological Processes -6.32323278 8 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0032891 negative regulation of organic acid transport GO Biological Processes -5.29413319 5 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034250 positive regulation of cellular amide metabolic process GO Biological Processes -3.04911747 8 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0034605 cellular response to heat GO Biological Processes -2.32243354 4 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035966 response to topologically incorrect protein GO Biological Processes -3.19318664 8 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway GO Biological Processes -4.66781085 9 More
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO Biological Processes -3.41852381 6 More
GO:0043030 regulation of macrophage activation GO Biological Processes -14.6396218 15 More
GO:0043032 positive regulation of macrophage activation GO Biological Processes -14.1432953 16 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -5.11653120 8 More
GO:0043236 laminin binding GO Molecular Functions -4.54309219 5 More
GO:0043277 apoptotic cell clearance GO Biological Processes -6.75865733 12 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043394 proteoglycan binding GO Molecular Functions -12.1259478 11 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045727 positive regulation of translation GO Biological Processes -1.57399763 5 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048265 response to pain GO Biological Processes -4.73205562 8 More
GO:0048266 behavioral response to pain GO Biological Processes -3.08353391 3 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050840 extracellular matrix binding GO Molecular Functions -6.18341292 8 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0050922 negative regulation of chemotaxis GO Biological Processes -8.57011989 17 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051592 response to calcium ion GO Biological Processes -7.43492702 23 More
GO:0051893 regulation of focal adhesion assembly GO Biological Processes -2.15133046 4 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070613 regulation of protein processing GO Biological Processes -7.71267127 10 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071622 regulation of granulocyte chemotaxis GO Biological Processes -10.3031127 11 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071813 lipoprotein particle binding GO Molecular Functions -15.1312842 12 More
GO:0071814 protein-lipid complex binding GO Molecular Functions -15.1312842 12 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0072341 modified amino acid binding GO Molecular Functions -2.85016161 6 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:0090109 regulation of cell-substrate junction assembly GO Biological Processes -2.15133046 4 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090288 negative regulation of cellular response to growth factor stimulus GO Biological Processes -9.39414218 23 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0099024 plasma membrane invagination GO Biological Processes -3.65307119 8 More
GO:0150116 regulation of cell-substrate junction organization GO Biological Processes -2.03755714 4 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901654 response to ketone GO Biological Processes -10.4509771 32 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901889 negative regulation of cell junction assembly GO Biological Processes -5.33337113 9 More
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -11.7829637 12 More
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -3.72261873 5 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1903317 regulation of protein maturation GO Biological Processes -7.52692728 10 More
GO:1903318 negative regulation of protein maturation GO Biological Processes -5.65848894 6 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO Biological Processes -8.41113232 25 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1905521 regulation of macrophage migration GO Biological Processes -12.9236434 12 More
GO:1905523 positive regulation of macrophage migration GO Biological Processes -10.7598894 9 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2000117 negative regulation of cysteine-type endopeptidase activity GO Biological Processes -4.79670615 8 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2000191 regulation of fatty acid transport GO Biological Processes -10.7141263 14 More
GO:2000192 negative regulation of fatty acid transport GO Biological Processes -4.25319477 3 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000379 positive regulation of reactive oxygen species metabolic process GO Biological Processes -15.0445998 16 More
GO:2001026 regulation of endothelial cell chemotaxis GO Biological Processes -8.98205881 11 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04115 p53 signaling pathway KEGG Pathway -6.32340535 9 More
hsa04145 Phagosome KEGG Pathway -11.4012504 17 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04350 TGF-beta signaling pathway KEGG Pathway -6.45304971 17 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa04512 ECM-receptor interaction KEGG Pathway -16.8587083 28 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05219 Bladder cancer KEGG Pathway -8.60591296 9 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NM_003246.4:c.2099A>G genomics myocardial infarction[diagnosis] myocardial infarction Zwicker JI et al. Blood. 2006
thrombospondin-1 proteomics poor predictor major adverse cardiovascular events[prognosis (bad)] ST elevation myocardial infarction Kaiser R et al. Clin Hemorheol Microcirc. 2013
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